“Somewhere, something incredible is waiting to be known.” ― Carl Sagan Current Biology

18th August 2014

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Elusive viral ‘machine’ architecture finally rendered
For half a century biologists have studied the way that the lambda virus parks DNA in the chromosome of a host E. coli bacterium and later extracts it as a model reaction of genetic recombination. But for all that time, they could never produce an overall depiction of the protein-DNA machines that carry out the work. In a pair of back-to-back papers in the Proceedings of the National Academy of Sciences, scientists produce those long-sought renderings and describe how they figured out how they should look.
Wenjun Tong, David Warren, Nicole E. Seah, Gurunathan Laxmikanthan, Gregory D. Van Duyne, and Arthur Landy. Mapping the {lambda} Integrase bridges in the nucleoprotein Holliday junction intermediates of viral integrative and excisive recombination. PNAS, August 2014 DOI: 10.1073/pnas.1413007111
Lambda uses this DNA-protein complex to insert its DNA into that of its E.coli host. Another complex, or machine, extracts the DNA later. Credit: Arthur Landy et al./Brown University

Elusive viral ‘machine’ architecture finally rendered

For half a century biologists have studied the way that the lambda virus parks DNA in the chromosome of a host E. coli bacterium and later extracts it as a model reaction of genetic recombination. But for all that time, they could never produce an overall depiction of the protein-DNA machines that carry out the work. In a pair of back-to-back papers in the Proceedings of the National Academy of Sciences, scientists produce those long-sought renderings and describe how they figured out how they should look.

Wenjun Tong, David Warren, Nicole E. Seah, Gurunathan Laxmikanthan, Gregory D. Van Duyne, and Arthur Landy. Mapping the {lambda} Integrase bridges in the nucleoprotein Holliday junction intermediates of viral integrative and excisive recombination. PNAS, August 2014 DOI: 10.1073/pnas.1413007111

Lambda uses this DNA-protein complex to insert its DNA into that of its E.coli host. Another complex, or machine, extracts the DNA later. Credit: Arthur Landy et al./Brown University

Tagged: Lambda viruse. coliDNAgeneticsbiologyscience

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    Ah memories of virology…
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