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For the first time, a team of chemists and engineers at Penn State University have placed tiny synthetic motors inside live human cells, propelled them with ultrasonic waves and steered them magnetically. The nanomotors, which are rocket-shaped metal particles, move around inside the cells, spinning and battering against the cell membrane.
"As these nanomotors move around and bump into structures inside the cells, the live cells show internal mechanical responses that no one has seen before," said Tom Mallouk, Evan Pugh Professor of Materials Chemistry and Physics at Penn State. "This research is a vivid demonstration that it may be possible to use synthetic nanomotors to study cell biology in new ways. We might be able to use nanomotors to treat cancer and other diseases by mechanically manipulating cells from the inside. Nanomotors could perform intracellular surgery and deliver drugs noninvasively to living tissues."
The researchers’ findings will be published in Angewandte Chemie International Edition on 10 February 2014. In addition to Mallouk, co-authors include Penn State researchers Wei Wang, Sixing Li, Suzanne Ahmed, and Tony Jun Huang, as well as Lamar Mair of Weinberg Medical Physics in Maryland U.S.A.
Caption: Optical microscope image of a HeLa cell containing several gold-ruthenium nanomotors. Arrows indicate the trajectories of the nanomotors, and the solid white line shows propulsion. Near the center of the image, a spindle of several nanomotors is spinning. Inset: Electron micrograph of a gold-ruthenium nanomotor. The scattering of sound waves from the two ends results in propulsion. Credit: Mallouk lab, Penn State University