“Somewhere, something incredible is waiting to be known.” ― Carl Sagan Current Biology

Promote Your Page Too

25th November 2013

Photo with 214 notes

Bacteria use lethal cytotoxins to evade antibiotic treatment
Bacterial tolerance is not just due to resistance, but also to the formation of persistent cells that have gone into a dormant state where they are no longer sensitive to antibiotics. On the molecular level, this process is controlled by a number of advanced cytotoxins produced by the bacteria themselves in order to survive. In Mycobacterium tuberculosis – the organism that causes tuberculosis – there are no fewer than 88 such toxins, all of which presumably help the organism to survive.
In a new article in the renowned journal Nature Communications, an international team of researchers with the participation of the Department of Molecular Biology and Genetics, Aarhus University, has revealed the mechanism behind one of these toxins – VapC20. It turns out that when the toxin is activated, it destroys the tuberculosis bacteria’s own protein ‘factory’ (the ribosome) by cleavage. The bacteria are thereby unable to produce proteins in the short term, and thus avoid the effect of antibiotics that also often attack the ribosome.

Bacteria use lethal cytotoxins to evade antibiotic treatment

Bacterial tolerance is not just due to resistance, but also to the formation of persistent cells that have gone into a dormant state where they are no longer sensitive to antibiotics. On the molecular level, this process is controlled by a number of advanced cytotoxins produced by the bacteria themselves in order to survive. In Mycobacterium tuberculosis – the organism that causes tuberculosis – there are no fewer than 88 such toxins, all of which presumably help the organism to survive.

In a new article in the renowned journal Nature Communications, an international team of researchers with the participation of the Department of Molecular Biology and Genetics, Aarhus University, has revealed the mechanism behind one of these toxins – VapC20. It turns out that when the toxin is activated, it destroys the tuberculosis bacteria’s own protein ‘factory’ (the ribosome) by cleavage. The bacteria are thereby unable to produce proteins in the short term, and thus avoid the effect of antibiotics that also often attack the ribosome.

Tagged: TuberculosisBacteriaantibiotic resistanceCytotoxinsBiologyScience

()

  1. bens3758 reblogged this from 23pairsofchromosomes
  2. zerocaloriegoodie reblogged this from currentsinbiology
  3. colietee reblogged this from somuchscience
  4. curiouseruntcuriouser reblogged this from currentsinbiology
  5. nature-of-reality reblogged this from currentsinbiology
  6. subjective-experience reblogged this from molecularlifesciences
  7. lonewalker reblogged this from currentsinbiology
  8. thsissilent reblogged this from raw-r-evolution
  9. raw-r-evolution reblogged this from dermoosealini
  10. dermoosealini reblogged this from molecularlifesciences
  11. zepidemiologus reblogged this from molecularlifesciences
  12. yeahbutmedschool reblogged this from molecularlifesciences
  13. unsaltedsodium reblogged this from errol--flynn and added:
    I was like: bla, bla, bla. Oh I get it!!!
  14. errol--flynn reblogged this from molecularlifesciences
  15. mustardbeck reblogged this from molecularlifesciences
  16. hotdogcephalopod reblogged this from molecularlifesciences
  17. the-electric-boogaloo reblogged this from molecularlifesciences
  18. stackedcrates reblogged this from molecularlifesciences
  19. astronomicona reblogged this from molecularlifesciences
  20. keepcalm-eatcake reblogged this from molecularlifesciences
  21. molecularlifesciences reblogged this from btlbkmn
  22. kindofdistracting reblogged this from revereche
  23. bugcthulhu reblogged this from revereche
  24. revereche reblogged this from currentsinbiology
  25. yuckydelgado reblogged this from ah-thenah
  26. ah-thenah reblogged this from currentsinbiology
  27. saimasaleem reblogged this from fyeahmedlab
  28. surgerynstuff reblogged this from nursingisinmyblood
  29. smilingsword reblogged this from crossroadsbluess
  30. crossroadsbluess reblogged this from currentsinbiology
  31. biologys reblogged this from currentsinbiology