“Somewhere, something incredible is waiting to be known.” ― Carl Sagan Current Biology

11th November 2013

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How Body Clock Affects Inflammation
A study published in the Nov. 8 edition of Science identifies a previously hidden pathway by which the body’s circadian clock controls the numbers of key inflammatory cells called interleukin-17-producing CD4+ T helper cells (TH17). The work could lead to new ways to rev up the body’s immune response to infection or dampen that response in the case of autoimmune diseases in which the body attacks its own tissues, said senior author Dr. Lora Hooper, Professor of Immunology and Microbiology and a Howard Hughes Medical Institute (HHMI) Investigator.
X. Yu, D. Rollins, K. A. Ruhn, J. J. Stubblefield, C. B. Green, M. Kashiwada, P. B. Rothman, J. S. Takahashi, L. V. Hooper. TH17 Cell Differentiation Is Regulated by the Circadian Clock. Science, 2013; 342 (6159): 727 DOI: 10.1126/science.1243884
Th17 Cell Lineage Diagram

How Body Clock Affects Inflammation

A study published in the Nov. 8 edition of Science identifies a previously hidden pathway by which the body’s circadian clock controls the numbers of key inflammatory cells called interleukin-17-producing CD4+ T helper cells (TH17). The work could lead to new ways to rev up the body’s immune response to infection or dampen that response in the case of autoimmune diseases in which the body attacks its own tissues, said senior author Dr. Lora Hooper, Professor of Immunology and Microbiology and a Howard Hughes Medical Institute (HHMI) Investigator.

X. Yu, D. Rollins, K. A. Ruhn, J. J. Stubblefield, C. B. Green, M. Kashiwada, P. B. Rothman, J. S. Takahashi, L. V. Hooper. TH17 Cell Differentiation Is Regulated by the Circadian Clock. Science, 2013; 342 (6159): 727 DOI: 10.1126/science.1243884

Th17 Cell Lineage Diagram

Tagged: T helper cellsInflammationImmune cellscircadian rhythmclockBiologyScience

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  14. ipit-sastrodinata reblogged this from currentsinbiology and added:
    Duh kacau banget irama circadian semester ini :/
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  17. tinkswish reblogged this from currentsinbiology and added:
    "Light-cycle disruption elevated intestinal TH17 cell frequencies and increased susceptibility to inflammatory disease....
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  24. thisiskat reblogged this from currentsinbiology and added:
    Circadian clocks regulate numerous physiological processes that vary across the day-night (diurnal) cycle, but if and...
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    from-dust-of-stars: awesome n exciting research!