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How Body Clock Affects Inflammation
A study published in the Nov. 8 edition of Science identifies a previously hidden pathway by which the body’s circadian clock controls the numbers of key inflammatory cells called interleukin-17-producing CD4+ T helper cells (TH17). The work could lead to new ways to rev up the body’s immune response to infection or dampen that response in the case of autoimmune diseases in which the body attacks its own tissues, said senior author Dr. Lora Hooper, Professor of Immunology and Microbiology and a Howard Hughes Medical Institute (HHMI) Investigator.
X. Yu, D. Rollins, K. A. Ruhn, J. J. Stubblefield, C. B. Green, M. Kashiwada, P. B. Rothman, J. S. Takahashi, L. V. Hooper. TH17 Cell Differentiation Is Regulated by the Circadian Clock. Science, 2013; 342 (6159): 727 DOI: 10.1126/science.1243884